Nuclear Receptor Coregulators: Judges, Juries, and Executioners of Cellular Regulation

Nuclear receptor coregulators: cellular and molecular biology.

Nuclear receptor coregulators are coactivators or corepressors that are required by nuclear receptors for efficient transcripitonal regulation. In this context, we define coactivators, broadly, as molecules that interact with nuclear receptors and enhance their transactivation. Analogously, we refer to nuclear receptor corepressors as factors that interact with nuclear receptors and lower the t...

Judges, Juries, and Scientific Evidence

Topic 1.2 Nuclear receptor coregulators*

It has been postulated that nuclear receptors (NRs) regulate transcription via interactions with chromatin and the basal transcription machinery at the promoters of genes. Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulating positive or negative receptor activity. A large number of putative coactivators have been isolated, several of w...

Quilt Judges and Juries: Hard Questions

Punitive Damages: How Judges and Juries Perform

A substantial recent literature has documented the inability of jurors to make sound decisions with respect to punitive damages, particularly for health, safety, and environmental torts. Included in this literature are experimental studies documenting the better performance of judges than jurors for the same case scenarios. Recent research by Eisenberg et al. (2002) has suggested, however, that...